Lyman BioPharma Consulting LLC

Advice and Resources for the Biotech Industry

Advice and Resources for the Biotech Industry

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I have assembled an updated list of Northwest drug-centered biotechnology companies for the benefit of the local biotech community. Also included here are companies headquartered elsewhere, but with research or manufacturing groups in our area. Publicly traded companies are in Bold. Hyperlinks will take you to the company websites; no hyperlink means no website. Please email me with any corrections or updates. Click here to see a list of these companies sorted by the technological approaches they have taken towards drug development. Click here to go to my Seattle Biotech Graveyard page detailing the fates of companies that are no longer with us in Seattle. Finally, click here to learn about my consulting services, or use the links above.

Most of the companies listed here are headquartered in the Puget Sound region, although the list also includes other WA State companies and a few in OR and Vancouver, BC.


13Therapeutics - Portland based anti-inflammatory peptide developer
AbSci - Portland based company develops and produces monoclonal antibodies
Achieve Life Sciences was created in Jan. 2017 by reverse merger of OncoGenex and Achieve; works on cancer and smoking cessation drugs
Acucela - Drug therapies for blinding eye diseases (Note: publicly traded on the Tokyo Stock Exchange)
Aequus BioPharma - Developing improved version of the drug ACTH by fusing it to NDP-MSH. It appears to have deemphasized its work on genetic polymer technology for biologics
Agave Pharma, Inc. - RNAi therapeutics and delivery
Ajuga Biosciences - Developing terpene based chemicals from mint
Akeaso Immunotherapeutics - Focused on development antibody drug conjugates to modify the behavior of inflammatory lymphocytes
Alder Biopharmaceuticals - Yeast monoclonal antibodies to treat diseases
Algomedix - Focused on developing transient receptor potential therapeutics for chronic pain
Allon Therapeutics - Focus on neurodegenerative diseases in BC
Alpine Immune Sciences - Immunotherapy company headed by former Dendreon CEO Mitch Gold (went public via merger in 2017)
Aminex Therapeutics - Developing immuno-oncology based therapeutics based on polyamine biology
Amkor Pharma - Virtual biotech, clinical focus on neuroprotection
AmpliPhi - Seattle office of London based bacteriophage company for bacterial infections
Anergix LLC - Developing peptide delivery MS treatments; admin office in Seattle
Apogen Biotechnologies - Accelerator company developing drugs to combat cancer drug resistance in tumors by inhibiting a DNA cytosine deaminase enzyme
Aptevo Therapeutics - Emergent BioSolutions spin-off launched in mid 2016, using immunotherapy technology acquired from Trubion
Arbutus Biopharma (formerly Tekmira) - BC developer of antiviral drugs
Arrowsmith Technologies - Antibodies trap chemo for brain cancer
Artemisia BioMedical - Novel artemisinin-based therapeutics
Artielle Immunotherapeutics - Therapies for autoimmunity in OR
Arzeda - Uses computational approaches to make novel enzymes
Atossa Genetics - Working up breast cancer catheters and drugs
Aurelius Biotherapeutics - Emerging veterinary immunotherapeutic and diagnostic company focused on the treatment of canine lymphoma
Avalyn Pharma - (formerly Genoa Pharmaceuticals) - Bruce Montgomery led startup working on inhaled drugs for idiopathic pulmonary fibrosis
Ave Maria (AVM) Biotech - Working on ethical human therapeutics
Beat BioTherapeutics - Working on gene therapy for repairing damaged hearts
Bio Architecture Lab - Spinoff from David Baker's lab at the U. Washington is engaged in the development of low cost, scalable, and sustainable biomass
Blaze Bioscience - Developing a “paint” to identify tumor cells in situ for surgeons
Bluebird Bio - Seattle branch of gene therapy/cancer IO/gene editing company
Bullet Biopharma - Start-up focused on the development of a proprietary platform, the BBP protein scaffold domain
Cancer Targeted Technology - Unique small molecule enzyme inhibitors for imaging and drug delivery
Cardeas Pharma - New startup of entrepreneur Bruce Montgomery; inhaled antibiotics
Cascade ProDrug - In Eugene, developing vinca alkaloid derivatives as anticancer treatments
Cascadia Life Sciences - Unknown focus
Celgene - Seattle branch of multinational drug company; it’s immune-oncology center of excellence
CisThera - Drugs for cancer, autoimmune disease, and others
Clene Nanomedicine - Developing drugs based on a nano suspension technology
Cocrystal Discovery - Developing mall molecule anti-viral drugs
Compliment Corp - Novel engineered proteins derived from the non-immunogenic portion of adenoviruses that increase the efficacy and decrease the toxicity of widely used cancer therapies
CTI Biopharma (formerly Cell Therapeutics Inc) - Developing small molecules for cancer
CytoDyn - Develops monoclonal antibodies for treating HIV (Vancouver, WA)
DesignMedix - Portland based small molecule drug combination company
Dimera - Portland based, discovering small molecules for coronary heart disease in women
DMD Therapeutics - New start-up headed by serial entrepreneur Ron Berenson
Durable Therapeutics - No description available
Emergent BioSolutions - Developing small modular immunopharmaceuticals acquired from Trubion as well as vaccines
EpiThany - Immunotherapy startup to commercialize work of Nora Disis for cancer therapies
Etubics - Developing vector vaccines and immunotherapies for infectious diseases
Fabion Pharmaceuticals - Startup focusing on developing bispecific antibodies for cancer treatment
Faraday Pharmaceuticals - Developing elemental reducing agents for protection against reperfusion injury
Floragenex - Genomic services: discovery, genotyping, and analytics
Gamma Therapeutics - Drugs and diagnostics platform built around clotting protein gamma prime fibrinogen
Gilead - Lung disease discovery group in Seattle; HQ in CA
Good Therapeutics, Inc. - Developing biotherapeutic proteins that regulate their own activity in response to metabolic signals
Halo-Bio RNAi Therapeutics - Novel asymmetric RNAi therapeutics
Helix BioMedix - Bioactive peptides for skin disorders, infections
Icogenex - Working to identify molecules for the treatment of neurodegenerative disease
Imdaptive - Profiles changes in the adaptive immune system
Immune Design - Developing immuno-oncology therapeutics and vaccines
Immusoft - Technology platform to reprogram the immune system
Implicit Bioscience - Small molecule dipeptides as anti-microbials and mAbs
Inmedix - Developing autoimmune disease drugs (Seattle branch)
Integrated Diagnostics - Developed a molecular blood test for assessment of pulmonary nodules
ISM Therapeutics - Therapeutics based on inositol signaling
Juno Therapeutics - Seattle/NY immunotherapy startup launched with $120M in 2013, bought by Celgene in Jan. 2018
Just Therapeutics - Expanding patient access to biotherapeutics via innovative cost savings solutions
KinDex Therapeutics - Focus on metabolic regulatory networks; focus on women’s health
Kineta - Small molecule drugs that enhance immunity; also focused on neuroscience and rare diseases
KPI Therapeutics - Developing drugs for autoimmunity; aligned with Seattle biotech Kineta
Light Sciences Oncology - Light activated oncology products
MalarVx - Novel vaccine approaches to eradicate malaria
Mavupharma - Developing non-nucleotide, conditional modulators of the STING pathway to treat cancer and infectious disease.
M3 Biotechnology - Regulating protein-protein interactions for treating Parkinson's and Alzheimer's diseases; WSU spinout located in Fluke Hall at the UW in Seattle
Lumen Bioscience (formerly Matrix Genetics) - Engineering blue green algae to make renewable fuels
Metheor Therapeutics - Developing small molecule inhibitors of DNA methyltransferases
Najit Technologies - Creating vaccines for West Nile virus and Yellow Fever virus; in Portland
NeuMedics - Developing drug to prevent diabetic macular edema
Nohla Therapeutics - Fred Hutch spin out developing umbilical cord blood for transplants and restoring white blood cells
North Coast Biologics - Rabbit high-affinity antibody based drugs
Novo Nordisk Obesity Research Unit - Opening in Seattle 2015
Obenomics - Small molecule approach to treating obesity
Omeros - Clinical stage company, focus is on inflammation, CNS
Oncofactor - Accelerator startup focused on novel cancer therapy
OncoResponse - Based in Seattle/Houston, screens B cell responses of cancer “Elite Responders” to uncover new targets/antibodies for immunotherapy
Oncotherapy Solutions LLC - Developing anti-cancer drugs for solid tumors
Onkor Pharmaceuticals - Virtual company making cancer drugs
Oricula Therapeutics - Developing medicines to protect hearing
Pacific Northwest Biotechnology - Small molecule drug discovery
PAI Life Sciences (formerly Protein Advances Inc.) - Developing antigen for diagnostics and vaccines
Pembient - Bioengineering wildlife products in order to save wildlife
PharmAthene - Merging with Theraclone in 2013; will focus on antibody drug development and vaccines; HQ in Seattle
Phytelligence - Fruit plantlet genetics and propagation
ProteoTech - Small molecule development for amyloid diseases
Proniras - Developing the drug Tezampanel as a potential treatment for nerve agents; part of Accelerator
PvP Biologics - Aiming to commercialize an orally taken enzyme that breaks down gluten for treating celiac disease. Labs are in Seattle, with management in San Diego.
Qwell Pharmaceuticals - Developing small molecule drugs from plant sources
RAiN Bioscience - Developing drugs for difficult to treat diseases using a delivery technology for RNA-targeting oligomers
RareCyte - Single cell analysis to enable the development of liquid biopsies
Resolve Therapeutics - Start up developing a protein based drug to treat lupus
Revalesio Corporation - Developing treatments for inflammatory disease in Tacoma
RJS Biologics - Adds affinity-tags to drive therapeutic compounds into cancer cells
Rodeo Therapeutics - Developing 15-PGDH inhibitors for the treatment of IBD and promoting blood cell reconstitution after bone marrow transplant
Seattle Genetics - Monoclonal antibodies for cancer treatment
Seattle Life Sciences - Zymogenetics spin-off in 2009; may no longer be in business
Silverback - Peter Thompson’s new biotech (launched in 2016), still in stealth mode
Sound Biologics - Biotech company with a focus on cancer, inflammatory and autoimmune diseases
Sound Pharmaceuticals - Drugs to prevent hearing loss
Syntrix Biosystems - Novel therapeutics and research platforms for treating pain
SystImmune - Newly established antibody therapeutics company focused on cancer treatments
Theraclone Sciences (was Spaltudaq) - Developing therapeutic antibodies for pandemic and seasonal influenza; ended potential merger with PharmAthene in 2013
TRIA Biosciences - Advancing conjugated vaccines
Twin Strand Biosciences - Uses duplex sequencing technology to improve detection of DNA mutations; CEO is Seattle biotech veteran Michael Kranda
UbiVac - Portland based developer of therapeutic vaccines for cancer and infectious diseases
Universal Cells - Developing off the shelf universal donor stem cells; acquired by Astellas in Feb. 2018
V-Gene - Antibody based drug development
Virvio - Working on the development of novel computationally designed proteins to treat influenza
Virtici Corporation - Startup that works with people to identify new science ideas and bring them into development
Zymeworks - BC based computational biology drug platform for creating antibodies and protein therapeutics